Dr. Ren was trained as a developmental biologist studying vertebrate embryogenesis. Moving from developmental biology to bioengineering, over the past ten years, he combines extracellular matrix and stem cell engineering to regenerate functional, vascularized tissues (lung, intestine and islet) to deliver specific biological functions. Current research in his lab at CMU investigates and engineers cell-cell and cell-extracellular interactions during the biofabrication of functional tissues, in particular the lung. Their recent work describes strategies for modeling human heart and lung co-development using stem cell derived multi-lineage differentiation and for precise control of epithelial polarity in engineered lung organoid. These topics will be covered in this talk.